Table 5.
Association between XRCC1 condon 194 and 399 polymorphisms and NPC risk stratified by age range (yr)
| Genotype | <60 | ≥60 | ||||||
| Cases | Controls | Adjusted ORa (95% CI) | P value | Cases | Controls | Adjusted ORa (95%CI) | P value | |
| XRCC1 Arg194Trp | ||||||||
| Arg/Arg | 189 | 190 | 1.00 | 42 | 45 | 1.00 | ||
| Arg/Trp | 151 | 179 | 0.85(0.62–1.16) | 0.30 | 17 | 38 | 0.48(0.23–0.99) | 0.05* |
| Trp/Trp | 17 | 37 | 0.52(0.28–0.96) | 0.04 | 1 | 6 | 0.27(0.03–2.52) | 0.25 |
| XRCC1 Arg399Gln | ||||||||
| Arg/Arg | 210 | 228 | 1.00 | 27 | 42 | 1.00 | ||
| Arg/Gln | 131 | 159 | 0.83(0.61–1.13) | 0.23 | 25 | 41 | 0.84(0.38–1.86) | 0.67 |
| Gln/Gln | 22 | 25 | 1.09(0.58–2.05) | 0.79 | 10 | 6 | 1.75(0.48–6.44) | 0.40 |
aAdjust OR were calculated with the XRCC1 194Arg/Arg or 399Arg/Arg genotype as the reference group and adjusted for sex, smoking status.
*P-value was not significant after Bonferroni's correction.