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. Author manuscript; available in PMC: 2006 Aug 18.
Published in final edited form as: Neuron Glia Biol. 2004 Nov;1(4):351–363. doi: 10.1017/s1740925x05000219

Fig. 2. The glial response to motor-skill learning.

Fig. 2

The glial response to motor-skill learning (A) is transient and requires persistent motor skill training for maintenance, whereas the increase in synapses per neuron (B) is stable in the absence of continued training. AC (acrobat) rats were trained on a motor skill learning task, whereas MC (motor control) animals ran on a treadmill but were not given an opportunity for learning. Animals in the Early group either participated in training (AC) or exercised (MC) for 10 days, animals in the Continuous group participated for 38 days, and animals in the Delay group participated for 10 days and then training (or exercise) was discontinued for the following 28 days before histological examination. * indicates P<0.05 for the comparison between the MC and AC animals of a particular group (Early, Continuous and Delay). Modified, with permission, from Kleim et al. (1997) and from Kleim et al. (in preparation).