Figure 1.

Adenoviral particles. Three major coat proteins make up the icosahedral adenovirus particle. The most abundant coat protein is hexon. which makes up 240 capsomeres per article. Twelve fiber trimers are loated at each icosahedral vertex. The knob portion of fiber is responsible for cell binding through the cellular receptor CAR. At the base of each fiber trimer is the penton capsomere. An exposed RGD motif in each of the 5 penton molecules binds cellular integrins and triggers internalization. CAR, coxsackie adenovirus receptor; RGD, Arg-Gly-Asp.