Table 1.

Demographic characteristics of the seven study patients

Patient	Age (years)	Weight (kg)	Height (cm)	SAPS II score	Urine output (ml/24 hours)a	Residual glomerular filtration rate (ml/min)b
1	65	76	170	42	300	<1
2	43	70	195	46	50	<1
3	51	76	165	28	1,650	5
4	71	89	178	64	0	0
5	46	61	183	65	150	<1
6	68	83	168	63	300	<1
7	68	88	163	64	100	<1

^aMean daily urine output during time of pharmacokinetic sampling. ^bCreatinine clearance measured at the inclusion; if necessary, continuous venovenous haemodiafiltration was stopped before enrollment to assess creatinine clearance. SAPS, Simplified Acute Physiologic Score.