Figure 6.

(A) Transcriptional activation of the RSV-LTR promoter-driven β-galactosidase reporter on cotransfection with BRCA1 over control empty vector. (B) Cotransfection of p300-enhanced BRCA1-dependent transcriptional activation in RK13 cells. Reduced amounts of BRCA1 were transfected in these cases to avoid saturation of the reporter. (C) Transfection of increasing amounts of p300 and constant amounts of a RSV-LTR promoter-driven β-galactosidase reporter into a tetracycline/doxycycline repressible BRCA1 HeLa cell line shows BRCA1-dependent p300 enhancement of RSV-LTR promoter activity.