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Oxidation of thioredoxin (Trx) by hydrogen peroxide (H2O2) leads to a change in shape of the molecule and the release of the transcriptional factor ASK1. Trx is then reduced again by Trx reductase, which allows it to again bind to ASK1 and inactivate this transcriptional factor. Through this mechanism the redox state of the cell can regulate the activity of the transcriptional factor ASK1.
