Table 1.
Changes in haemodynamic variables, acid-base status, reactive hyperaemia, and vasomotion
| Parameters | Group | Baseline | 1 hour | P |
| MAP (mmHg) | AVP/NE* | 64 ± 5 | 81 ± 12 | 0.047† |
| NE | 64 ± 9 | 66 ± 13 | ||
| CI (l/min per m2) | AVP/NE | 4.1 ± 1.2 | 3.8 ± 1.1 | 0.152 |
| NE | 3.5 ± 0.9 | 3.5 ± 0.8 | ||
| DO2I (ml/min/m2) | AVP/NE | 571 ± 140 | 526 ± 130 | 0.151 |
| NE | 482 ± 111 | 493 ± 119 | ||
| VO2I (mL/min/m2) | AVP/NE | 155 ± 39 | 157 ± 35 | 0.077 |
| NE | 131 ± 35 | 137 ± 41 | ||
| SvO2 (%) | AVP/NE | 72 ± 6 | 66 ± 13 | 0.583 |
| NE | 71 ± 9 | 70 ± 10 | ||
| NE requirements (μg/kg per min) | AVP/NE* | 0.75 ± 0.31 | 0.51 ± 0.19 | 0.36 |
| NE | 0.65 ± 0.23 | 0.76 ± 0.18 | ||
| Milrinone requirements (μg/kg per min) | AVP/NE | 0.44 ± 0.15 | 0.44 ± 0.16 | 0.025† |
| NE | 0.31 ± 0.2 | 0.29 ± 0.19 | ||
| pH | AVP/NE | 7.30 ± 0.12 | 7.30 ± 0.12 | 0.355 |
| NE | 7.33 ± 0.1 | 7.32 ± 0.08 | ||
| Lactate (mmol/l) | AVP/NE | 5.9 ± 6.7 | 6.6 ± 6.3 | 0.548 |
| NE | 7.6 ± 6.1 | 7.5 ± 5.6 | ||
| AUC pre-ischaemic | AVP/NE | 21.2 ± 9.4 | 16.7 ± 7.7 | 0.089 |
| NE | 15.3 ± 10.2 | 15.3 ± 9.0 | ||
| Magnitude of RH (%) | AVP/NE | 64 ± 57.2 | 70 ± 47.5 | 0.56 |
| NE | 49.4 ± 24.8 | 48.7 ± 41.7 | ||
| ODS pre-ischaemic (oscillations/min) | AVP/NE‡ | 15.73 ± 5.15 | 14.38 ± 7.31 | 0.055§ |
| NE | 7.49 ± 3.2 | 10.7 ± 3.81 | ||
| ODS reperfusion (oscillations/min) | AVP/NE‡ | 14.38 ± 4.85 | 13.78 ± 9.17 | 0.601§ |
| NE | 8.99 ± 3.92 | 10.7 ± 5.7 |
Data are expressed as mean values ± standard deviation. AUC, area under the curve; AVP, arginine vasopressin; CI, cardiac index; DO2I, systemic oxygen transport index; MAP, mean arterial pressure; NE, norepinephrine; ODS, oscillation of the Doppler signal; RH, reactive hyperaemia; SvO2, mixed venous oxygen saturation; VO2I, systemic oxygen consumption index. *significant difference over time; †, significant difference between groups; ‡, significant difference at baseline between groups; §, corrected for baseline differences.