Table 4.

Jadad scoring items and allocation concealment of each study eligible for meta-analysis

	Weg and colleagues, 1994 [16]	Anzueto and colleagues, 1996 [17]	Gregory and colleagues, 1997 [18]	Spragg and colleagues, 2003 [19]	Spragg and colleagues, 2004 [20]
Jadad scoring items
Was the study randomized?	Yes	Yes	Yes	Yes	Yes
Was the randomization method described and appropriate?	Yes	Yes	No	Yes	No
Was the study described as double-blind?	Yes	Yes	No	No	Yes
Was the method of blinding described and appropriate	Yes	Yes	No	No	Yes
Was there a description of withdrawals and dropouts?	Yes	Yes	Yes	No	Yes
Inappropriate method of randomization?	No	No	No	No	No
Inappropriate method of blinding?	No	No	No	No	No
Allocation concealment	Central office provided randomization assignment to study sites	Independent central facility provided randomization assignment to study sites	Not clearly stated	Centralized facility provided randomization assignment to study sites	Not clearly stated