Table 4.

Diagnostic and severity criteria for sinusoidal obstruction syndrome

Diagnostic criteria	Hepatomegaly
	Sudden weight gain (+ 2% of body weight)
	Jaundice (total bilirubin >34 μmol/l)
	Right upper quadrant pain
	No other cause:
	Budd-Chiari syndrome
	Sepsis
	Heart failure
	Graft versus host disease
Other symptoms	Cytolysis
	Gall bladder wall thickening
	Portal hypertension
	Multiple organ failure
	Thrombocytopenia
Severe sinusoidal obstruction syndrome	Multiple organ failure
	Thrombocytopenia
	Cytolysis with ASAT or ALAT >750 IU/l
	Confusion or disorientation
	Maximum total bilirubin or severity of weight gain

LDH, lactate dehydrogenase; TLS, tumour lysis syndrome.