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. 2002 Aug;76(16):8360–8373. doi: 10.1128/JVI.76.16.8360-8373.2002

FIG. 9.

FIG. 9.

Worm diagram of the crystal structure of E. coli RNase H (35). The C helix is represented by the region in red and yellow. Alpha-carbon positions are shown for W81, N84, R88, and G89, which correspond to Mo-MLV RT residues H594, I597, R601, and G602, respectively. The recent crystal structure of Mo-MLV RNase H (unpublished data) and the crystal structure of E. coli RNase H superimposed upon an HIV RNase H bound to RNA-DNA show that the C helix may contact the substrate. Side chains for W81, N84, and R88 point to the side of the helix that is proposed to face the primer-template (toward the viewer), while G89 faces the opposite side (away from the viewer). The primer-template is proposed to lie roughly above the model from the top to bottom of the figure. This figure was made with MOLSCRIPT and Raster 3D (20, 21).