TABLE 2.
Fc receptor cross-linking by dengue virus-antibody complexes fails to induce appreciable levels of RANTES in comparison to levels produced in response to active infection
| Conditiona | RANTES level (pg/ml) in:
|
|||||
|---|---|---|---|---|---|---|
| Cord blood-derived mast cells
|
KU812 cells
|
|||||
| Subject 1 | Subject 2 | Subject 3 | Expt 1 | Expt 2 | Expt 3 | |
| Medium | 7.8 | 81.3 | 7.8 | 7.8 | 6.2 | 120.7 |
| PMA + A23187 | 7.8 | 301.8 | 651 | 120.8 | 166.7 | 1,004.5 |
| UV-Den alone | 7.8 | 43.1 | 7.8 | 498.6 | 131.1 | 59.4 |
| UV-Den + 1:1,000 Ab | 7.8 | 7.8 | 36.4 | 739.6 | 205.1 | 36.1 |
| Den + NHS | 7.8 | 202.3 | 83.2 | 437.7 | 1,343.9 | 266.8 |
| Den + 1:1,000 Ab | 546.3 | 1,613.5 | 284.7 | 53,242.4 | 100,500.3 | 13,502.6 |
a
Den, dengue virus; Ab, antibody.