FIG. 3.

Confocal sections of VV-infected cells double labeled for DNA (DAPI) and p16 (A14L). BHK cells infected with MVA (A and B) and HeLa cells infected with WR (C and D) were fixed at 6 h postinfection and double labeled with DAPI (red) and anti-p16 (green). In panels A and C the DAPI labeling is shown alone, and in panels B and D the merge of DAPI and p16 labeling is shown. The arrows indicate clusters of p16 labeling in panels B and D and the corresponding area in panels A and C. Asterisks indicate a DNA factory region. N, nucleus.