FIG. 9.

Model for viral factory formation. (A) When expressed in the absence of other viral proteins, μNS forms globular phase-dense inclusions that travel along MTs toward the nucleus. When μ2(T3D^N) is coexpressed with μNS, it is recruited to μNS globular inclusions. (B) In a T3D^N-infected cell, μNS binds to cores and incorporates them into inclusions to generate a globular viral factory (VF). (C) μNS coats MTs when coexpressed with μ2(T1L), forming filamentous structures. (D) In a T1L-infected cell, cores bound by μNS are recruited to MTs by the μNS/μ2 association, forming a filamentous VF.