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. 2002 Aug;76(16):8420–8432. doi: 10.1128/JVI.76.16.8420-8432.2002

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Copyright © 2002, American Society for Microbiology

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FIG. 9. — Sensitization of cells to 5-FU-induced apoptosis occurs through a p53-dependent process. (A) Nucleosomal ladder assays for apoptosis in p53 wild-type cells expressing T1-708 (B6Kp53+/+/T1-708+Ras) and p53-null cells expressing T1-708 (B6Kp53−/−/T1-708+Ras), T1-127 (B6Kp53−/−/T1-127+Ras), or T251-708 (B6Kp53−/−/T251-708+Ras) after overnight treatment with the indicated amounts of 5-FU. (B) TUNEL assays for apoptosis in B6MEF expressing wild-type T antigen (B6MEF/T1-708) and either left untreated (none) or treated overnight with the indicated amount of 5-FU and in p53-null cells expressing wild-type T antigen (B6Kp53−/−/T1-708+Ras) and treated overnight with the indicated amount of 5-FU.