FIG. 1.

FV-specific production of IFN-γ (A) and IL-10 (B) by purified CD4⁺ T cells. CD4⁺ T cells were purified from spleens of H-2^b/b, H-2^a/b, or H-2^a/a mice at 8 days postinfection with FV-B. The CD4⁺ T cells were cultured with irradiated syngeneic spleen cells as APCs in the presence or absence of purified UV-inactivated FV. After 72 h, culture supernatants were analyzed for cytokine production by IFN-γ- or IL-10-specific ELISA. Data shown are the average values ± standard errors of the means (SEM) for four mice per group.