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. 2002 Aug;76(16):8383–8399. doi: 10.1128/JVI.76.16.8383-8399.2002

TABLE 1.

Genes modulated in DMVEC after KSHV infectionb

UG Cluster Gene ID Symbol cDNA array value for:
Name Function Groupa
I8 I9
Hs.75613 N39161 CD36 14.9 27.0 CD36 (thrombospondin receptor) Platelet-collagen adhesion A
Hs.110802 AA487787 VWF 4.6 9.3 von Willebrand factor Antihemophilic factor carrier A
Hs.12337 AA026831 KDR 3.9 4.3 VEGF receptor 2 Vascular development, angiogenesis A
Hs.75716 T49159 SERPINB2 2.3 2.9 Plasminogen activator inhibitor 2 Angiogenesis A
Hs.295944 L27624 TFPI2 −2.1 −3.5 Tissue factor pathway inhibitor 2 Inhibit trypsin, factor VII(a)/tissue factor A
Hs.1908 AA278759 PRG1 −2.1 −9.3 Proteoglycan 1, secretory granule Tissue development and maintenance A
Hs.77274 AA284668 PLAU −2.8 −10.6 Urokinase plasminogen activator Angiogenesis A
Hs.8966 H58644 TEM8 −5.0 −16.7 Anthrax toxin receptor Elevated during tumor angiogenesis A
Hs.78146 R22412 PECAM1 2.7 1.8 CD31 Expressed on cell intercellular junctions A
Hs.268107 AA423867 MMRN 9.3 5.0 Endothelial cell multimerin precursor Extracellular matrix, adhesion CA
Hs.81337 AA434102 LGALS9 3.3 2.4 Lectin, galactoside binding Cell adhesion CA
Hs.50964 AA411757 CEACAM1 2.7 3.5 CD66 antigen Cell adhesion CA
Hs.2340 R06417 JUP 2.0 2.4 Junction plakoglobin Cell adhesion CA
Hs.118787 R31321 TGFBI −2.6 −2.9 Transforming growth factor Inhibits cell adhesion CA
Hs.36131 AA167222 COL14A1 −3.3 −3.5 Collagen, type XIV, alpha 1 Interacts with type I collagen CA
Hs.179573 AA490172 COL1A2 −4.5 −10.1 Collagen, type I, alpha 2 Fibrillar forming collagen CA
Hs.156346 AA504348 TOP2A 4.3 4.7 Topoisomerase (DNA) II alpha DNA synthesis CD
Hs.69563 H59203 CDC6 3.7 2.6 CDC6 homolog Cell growth and differentiation CD
Hs.239 AA129552 FOXM1 3.5 3.5 Forkhead box M1 Cell proliferation CD
Hs.85137 AA608568 CCNA2 3.4 2.6 Cyclin A2 Regulators of CDK kinases CD
Hs.156346 AA504348 TOP2A 3.2 3.2 Topoisomerase (DNA) II alpha DNA replication CD
Hs.84113 AA284072 CDKN3 2.8 2.9 Cyclin-dependent kinase inhibitor 3 Cell growth and differentiation CD
Hs.166563 H73714 RFC1 2.6 2.3 Replication factor C (activator 1) 1 Activator of DNA polymerases CD
Hs.348669 AA459292 CKS1 2.6 2.2 CDC28 protein kinase 1 Cell growth and differentiation CD
Hs.79069 AA489752 CCNG2 2.4 1.8 Cyclin G2 Regulators of CDK kinases CD
Hs.75586 H84153 CCND2 2.2 2.7 Cyclin D2 Regulators of CDK kinases CD
Hs.179565 AA455786 MCM3 2.2 2.2 DNA replication licensing factor mcm3 Associates with DNA polymerase CD
Hs.78996 AA450265 PCNA 2.0 2.1 Proliferating cell nuclear antigen Cell growth and differentiation CD
Hs.115474 H94617 RFC3 1.9 1.9 Replication factor C (activator 1) 3 DNA strand elongation CD
Hs.154762 W52273 HRB2 −1.9 −3.8 HIV-1 rev binding protein 2 May be required for cell division CD
Hs.256290 AA464731 S100A11 −2.0 −3.7 S100 calcium binding protein A11 Cell cycle progression, differentiation CD
Hs.514 AA454146 CCNH −2.4 −2.0 Cyclin H Regulators of CDK kinases CD
Hs.103291 R66101 LOC51299 5.0 7.7 Neuritin Neurite outgrowth CS
Hs.296842 AA490477 4.0 6.4 Similar to nonmuscle myosin Cytokinesis and cell shape CS
Hs.79226 H20758 FEZ1 3.8 3.5 Zeta 1 Axonal outgrowth CS
Hs.195850 AA160507 KRT5 2.3 2.4 Keratin 5 Intermediate filament family CS
Hs.79307 AA236617 ARHGEF6 2.2 3.1 Rac/Cdc42 guanine exchange factor 6 Regulation of actin cytoskeleton CS
Hs.121576 W95682 MYO1B 2.0 3.1 Myosin IB Cytoskeleton CS
Hs.182265 AA464250 KRT19 1.8 1.8 Keratin 19 Cytoskeletal structural protein CS
Hs.160483 R62868 EPB72 1.8 2.4 Erythrocyte membrane protein Cytoskeleton CS
Hs.24178 R27680 EML2 −1.9 −2.5 Microtubule-associated protein-like protein 2 Assembly dynamics of microtubules CS
Hs.155524 T64878 PNUTL2 −1.9 −2.0 Peanut-like 2 (Drosophila) Cytoskeletal organization CS
Hs.12451 AA447196 EML1 −3.7 −7.1 Microtubule-associated protein-like protein 1 Assembly dynamics of microtubules CS
Hs.303649 AA425102 SCYA2 7.0 9.2 Monocyte chemotactic protein-1 Inflammation H
Hs.20144 R96668 SCYA14 5.5 38.9 CC-chemokine 14 Inflammation H
Hs.182579 R69307 LOC51056 5.1 2.2 Leucine aminopeptidase Interferon gamma induced H
Hs.83429 H54629 TNFSF10 4.2 3.8 Tumor necrosis factor superfamily Induces apoptosis H
Hs.82112 AA464525 IL1R1 3.8 7.8 Interleukin 1 receptor, type I Cell signalling H
Hs.285401 AA279147 CSF2RB 3.3 2.1 Colony-stimulating factor 2 receptor High-affinity receptor for IL-3, IL-5, CSF H
Hs.44532 N49629 UBD 2.0 2.8 Diubiquitin Gamma interferon induced H
Hs.237356 AA447115 SDF1 −2.0 −2.3 Stromal cell-derived factor 1 Chemokine H
Hs.12013 T70122 ABCE1 2.4 1.8 ATP-binding cassette Antipathogen response H
Hs.1869 AA488504 PGM1 5.3 3.3 Phosphoglucomutase 1 Breakdown and synthesis of glucose M
Hs.154654 AA448157 CYP1B1 5.1 10.9 Cytochrome P450, subfamily I Drug metabolims and lipid biosynthesis M
Hs.84190 R49999 SLC19A1 4.3 6.6 Solute carrier family 19, member 1 Folate transport M
Hs.76057 AA281030 GALE 2.5 2.5 Galactose-4-epimerase, UDP− Galactose metabolism M
Hs.268012 W31074 FACL3 2.5 2.1 Fatty-acid-coenzyme A ligase Lipid synthesis and fatty acid degradation M
Hs.59403 AA160852 SPTLC2 2.4 2.2 Serine palmitoyltransferase Sphingolipids M
Hs.183556 T70098 SLC1A5 2.2 2.5 Solute carrier family 1, member 5 Neutral amino acid transporter M
Hs.75694 AA482198 MPI 2.1 2.7 Mannose phosphate isomerase Mannosylation M
Hs.183868 N34827 GUSB 1.9 3.5 Glucuronidase, beta Degradation of dermatan sulfates M
Hs.75736 H15842 APOD 1.8 10.5 Apolipoprotein D Lipoprotein metabolism M
Hs.251415 N74025 DIO1 −1.8 −6.2 Deiodinase, iodothyronine, type I Oxidoreductase M
Hs.73875 H44956 FAH −2.0 −2.0 Fumarylacetoacetate hydrolase Fumarylacetoacetase M
Hs.234642 R91904 AQP3 −2.2 −2.3 Aquaporin 3 Small molecule transport M
Hs.306098 R93124 AKR1C1 −2.3 −2.8 Dihydrodiol dehydrogenase Metabolizes xenobiotics M
Hs.81454 T61308 KHK 1.8 2.0 Ketohexokinase (fructokinase) Transferase M
Hs.576 N95761 FUCA1 1.9 1.8 Fucosidase, alpha-L-1, tissue Glycosyl hydrolases M
Hs.79187 N31467 CXADR 7.2 8.6 Coxsackie virus/adenovirus receptor Pathogenic invasion O
Hs.75737 AA164439 PCM1 3.9 3.3 Perioentriolar material 1 Interacts with centrosome O
Hs.3314 AA070226 SEPP1 3.5 3.5 Selenoprotein P, plasma, 1 Oxidative stress response O
Hs.284186 AA495846 3.2 3.3 Transcription factor forkhead-like 7 Binding of freac-3 and freac-4 O
Hs.74471 AA487623 GJA1 2.3 2.2 Gap junction protein, alpha 1 Cell-to-cell communication O
Hs.153487 AA485996 STAM −1.8 −2.0 Signal transducing adaptor molecule 1 Signal transduction O
Hs.234680 H26176 FER1L3 −2.1 −3.8 Myoferlin (for-1 like protein 3) Role in membrane regeneration O
Hs.13046 AA453335 TXNRD1 −2.1 −3.9 Thioredoxin reductase 1 Thioredoxin reductase (NADPH) O
Hs.36927 AA485036 HSP105B −2.1 −1.8 Heat shock 105kD Heat shock response O
Hs.75510 AA465051 ANXA11 −2.6 −2.3 Annexin A11 Phospholipid-binding protein O
Hs.56023 AA262988 BDNF −2.7 −5.4 Brain-derived neurotrophic factor Neural growth factor O
Hs.89137 AA464566 LRP1 −2.7 −3.3 Low-density lipoprotein-related protein Binds to apoE-containing lipoproteins O
Hs.296323 H75599 SGK −2.7 −3.2 Serum/glucocorticoid-regulated kinase Stress response O
Hs.135084 AA599177 CST3 −3.4 −2.1 Cystatin C Inhibitor of cysteine proteinases O
Hs.8265 R97066 TGM2 −3.6 −4.5 Transglutaminase 2 Protein modification O
Hs.790 AA495936 MGST1 −6.6 −9.4 Microsomal glutathione S-transferase Conjugation of reduced glutathione O
Hs.93002 AA430504 UBE2C 4.3 3.5 Ubiquitin-conjugating enzyme E2C Ubiquitination PD
Hs.155485 H78483 HIP2 3.3 2.0 Ubiquitin-conjugating enzyme e2-25 Huntington interacting protein 2 PD
Hs.75275 AA447528 UBE4A 2.2 3.5 Ubiquitination factor E4A Ubiquitination PD
Hs.1565 AA442095 NEDD4 −1.9 −9.0 NEDD-4 Ubiquitination PD
Hs.84084 AA046411 APPBP2 6.8 3.6 Amyloid beta precursor protein Vesicie sorting PS
Hs.20830 N69491 KNSL2 2.4 2.3 Kinesin-like 2 Microtubule gliding PS
Hs.1050 AA480859 PSCD1 2.4 2.5 Pleckstrin homology Protein sorting, membrane trafficking PS
Hs.91728 AA458994 PMSCL1 3.2 2.2 Polymyositis/scleroderma autoantigen 3 processing of the 7s pre-MA PT
Hs.79306 AA193254 EIF4E 3.0 1.8 Eukaryotic translation initiation factor Transcription factor T
Hs.78995 AA234897 MEF2C 2.7 2.4 MADS box transcription Transcriptional activator T
Hs.54452 AA280931 ZNFN1A1 2.4 2.2 Zinc finger protein, subfamily 1A Transcriptional activator T
Hs.33287 W87611 NFIB 2.2 2.9 Nuclear factor I/B Transcription regulation T
Hs.81328 W55872 NFKBIA 2.2 1.8 NF-KAPPAB INHIBITOR ALPHA Transcription factor T
Hs.181163 H93087 HMG17 2.1 1.8 High-mobility group protein 17 Bind to nucleosomal DNA T
Hs.154095 AA443659 ZNF143 2.0 3.9 Zinc finger protein 143 Transcriptional activator T
Hs.79353 W33012 TFDP1 2.0 2.1 Transcription factor Dp-1 Transcription regulation T
Hs.7943 R63137 RMP −2.1 −2.3 RPB5-mediating protein Transcription regulation from Pol II T
Hs.159223 AA434487 NAB2 −2.2 −2.1 NGFI-A binding protein 2 Transcriptional corepressor T
Hs.89657 AA292583 TAF10 −2.4 −1.8 TAF10 RNA polymerase II TFIID complex T
Hs.159223 AA434487 NAB2 −2.4 −2.4 NGFI-A binding protein 2 Transcriptional repressor T
Hs.2780 AA418670 JUND 5.2 7.8 jun-D proto-oncogene Transcription regulation TG
Hs.100724 AA088517 PPARG 4.3 6.0 PPAR gamma Adipocyte differentiation TG
Hs.75424 AA457158 ID1 4.0 6.1 Inhibitor of DNA binding 1 Transcription regulation TG
Hs.184585 AA464644 LMO2 3.5 7.8 LIM domain only 2 (rhombotin-like 1) Hematopoietic development TG
Hs.179718 AA456878 MYBL2 3.3 6.1 Myb-related protein b (b-myb) Oncogenesis TG
Hs.2969 W69471 SKI 3.0 5.9 ski oncogene Oncogenesis TG
Hs.22026 R16604 2.9 3.8 Similar to transmembrane 4 Expressed in endothelial cells and tumors TG
Hs.10526 T59334 CSRP2 2.7 2.3 Cysteine-and glycine-rich protein 2 Development and cellular differentiation TG
Hs.81665 N20798 KIT 2.6 5.0 c-kit Hematopoietic development TG
Hs.117078 AA436591 2.6 2.9 Cellular proto-oncogene (c-mer) Oncogenesis TG
Hs.31137 T69540 PTPRE 2.4 2.6 Protein tyrosine phosphatase Oncogenesis TG
Hs.89695 AA001614 INSR 2.1 3.4 Insulin receptor Cell growth and maintenance TG
Hs.162 H79047 IGFBP2 2.1 3.9 IGF binding Cell growth and differentiation TG
Hs.1103 R36467 TGFB1 2.1 2.4 Transforming growth factor, beta 1 Proliferation, differentiation, apoptosis TG
Hs.25155 R24543 NET1 1.9 2.7 Neuroepithelial cell transforming gene Oncogenesis TG
Hs.194143 H90415 BRCA1 1.9 2.2 Breast cancer 1, BRCA 1 Transcriptional activator TG
Hs.326035 AA486628 EGR1 1.8 2.2 Early growth response 1 Transcriptional regulator TG
Hs.61796 AA399334 TFAP2C −1.8 −2.1 Transcription factor AP-2 gamma Oncogenesis TG
Hs.129914 AA425238 RUNX1 −2.0 −1.4 Runt-related transcription factor Oncogenesis TG
Hs.75551 AA235332 RSU1 −2.2 −1.8 Ras suppressor protein 1 Inhibits Ras signaling TG
Hs.279860 R09634 TPT1 −2.6 −2.1 Tumor protein Unknown TG
Hs.1298 R98851 MME −5.4 −8.1 Membrane metallo-endopeptidase Marker of acute lymphocytic leukemia TG
Hs.23582 AA454810 TACSTD2 −5.4 −2.3 Transducer 2 Growth factor receptors TG
Hs.274313 AA478724 IGFBP6 −1.9 −4.7 Insulin-like growth factor binding Cell growth inhibitor TG
Hs.325823 H69048 6.6 16.8 Similar to ZN91 Unknown U
Hs.325823 R63109 4.9 8.0 Novel Unknown U
Hs.170234 R69677 4.7 14.0 Novel Unknown U
Hs.38516 W02617 4.6 12.0 Similar to developmental protein Unknown U
Hs.8769 N57594 BCMP1 3.9 4.2 Brain cell membrane protein 1 Homology to Wikott-Aldrich syndrome
Hs.23044 W00895 MGC16386 3.5 3.1 Novel Unknown U
Hs.107528 T67558 AIG-1 3.5 3.4 Androgen-induced protein Unknown U
Hs.111577 AA034213 ITM3 3.5 6.3 Integral membrane protein 3 Unknown U
Hs.51615 T70413 3.2 4.7 Novel Unknown U
Hs.16951 R91083 2.9 3.8 DKFZP586P2219 Unknown U
Hs.16951 T85698 2.9 3.5 Novel Unknown U
Hs.28456 R63982 2.9 3.4 Novel Unknown U
Hs.28456 H80158 2.9 8.9 Novel Unknown U
Hs.107528 R01796 AIG-1 2.7 3.2 Androgen-induced protein Unknown U
Hs.28783 R23302 KIAA1223 2.7 2.1 KIAA1223 protein Unknown U
Hs.20558 R70925 FLJ20345 2.6 2.1 Novel Unknown U
Hs.104859 T66936 2.5 2.8 DKFZp762E1312 Unknown U
Hs.151334 H65042 2.5 3.9 Novel Unknown U
Hs.326416 N55339 2.5 3.0 Novel Unknown U
Hs.191558 R06370 2.4 3.4 Novel Unknown U
Hs.191558 N91307 2.3 2.7 Novel Unknown U
Hs.191558 R79935 2.2 2.0 Novel Unknown U
Hs.26516 N72697 FLJ10604 2.1 4.6 Novel Unknown U
Hs.13041 T67104 2.1 2.8 Novel Unknown U
Hs.13041 AA452909 2.1 3.6 Novel Unknown U
Hs.13041 AA430744 2.1 2.0 Novel Unknown U
Hs.13041 R28344 2.0 2.3 Novel Unknown U
Hs.180059 N67039 1.9 1.8 Novel Unknown U
Hs.19717 R11532 1.9 2.2 Novel Unknown U
Hs.64313 T66828 1.8 2.3 Novel Unknown U
Hs.122546 H83176 FLJ23017 1.8 3.2 Novel Unknown U
Hs.20654 R10682 1.8 2.3 Novel Unknown U
Hs.38163 H63202 1.8 6.1 Hypothetical protein Unknown U
Hs.38163 R06507 1.8 1.9 Novel Unknown U
Hs.38163 AA452909 1.8 3.3 Novel Unknown U
Hs.23016 N53172 RDC1 1.8 4.6 RDC1 G protein-coupled receptor Unknown U
Hs.18878 R00332 EGLN3 1.8 2.2 EGL nine homolog 3 Unknown U
Hs.6349 AA432023 BC008967 −1.8 −2.6 Novel Unknown U
Hs.37308 H56438 −1.8 −1.9 Novel Unknown U
Hs.187447 T97870 −1.8 −2.4 Novel Unknown U
Hs.37623 H58834 −1.8 −1.9 Novel Unknown U
Hs.79123 AA457047 KIAA0084 −1.9 −2.7 Novel Unknown U
Hs.297929 R67991 −1.9 −5.6 Novel Unknown U
Hs.20588 H66312 PPY2 −2.0 −2.1 Pancreatic polypeptide 2 Unknown U
Hs.165067 H53316 −2.0 −3.3 Novel Unknown U
Hs.170198 AA459109 KIAA0009 −2.0 −3.2 Novel Unknown U
Hs.170198 N91330 −2.0 −2.7 Novel Unknown U
Hs.82141 H64850 −2.0 −2.5 Novel Unknown U
Hs.271686 R87194 −2.1 −3.1 Novel Unknown U
Hs.351310 N69540 −2.2 −1.8 Novel Unknown U
Hs.285519 AA447098 −2.2 −3.4 Novel Unknown U
Hs.285519 AA455538 −2.3 −6.2 Novel Unknown U
Hs.35453 R95811 −2.7 −3.5 cDNA DKFZp761G151 Unknown U
Hs.78019 H79234 −2.9 −2.6 Novel Unknown U
Hs.78019 AA284568 −3.3 −3.6 Novel Unknown U
a

Genes are organized into the following groups: A, angiogenesis; CA, cell adhesion; CD, cell division; CS, cell shape; H, host defense; M, metabolism; O, other; PD, protein degradation; PS, protein sorting; PT, protein translation; T, transcription; TG, tumorigenesis; U, unknown.

b

Boldface type indicates down regulated genes.