Table 2.

IR analyses of long bones of mutant and transgenic mice

Animal model	Finding relative to WT	Reference
Type X collagen transgenic	No bone or cartilage phenotype	[25]
Osteocalcin KO	Cortical bone increased mineral content, decreased crystal size	[26]
Matrix glia protein KO	Trabecular mineral content increased, crystal size increased	[27]
Biglycan KO	Cortical & Trabecular bone—decreased mineral content, increased crystal size	[28]
Osteopontin KO	Increased mineral content, increased crystal size	[29]
Osteonectin KO	Increased mineral content, increased crystal size	[30]
Dentin matrix protein 1 KO	Decreased mineral content, increased crystal size	[31]
Tissue non-specific alkaline phosphatase KO	Decreased mineral content	[12,13]
IGF-binding protein 5, TG	Lower mineral content—no change in crystal size	[32]
Vitamin D receptor TG	No change in mineral properties	[33]
TGF-beta KO	Decreased mineral content, decreased crystal size	[34]