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. Author manuscript; available in PMC: 2006 Aug 22.
Published in final edited form as: J Biol Chem. 2006 May 4;281(30):21332–21344. doi: 10.1074/jbc.M603814200

FIGURE 7. Activity of Css IV on Nav1.2 channels with mutations of hydrophobic amino acid residues in the IIS4 segment.

FIGURE 7

Conductance-voltage relationships of wild-type Nav1.2 and mutant channels in the presence of 200 nm Css IV with a 1-ms prepulse to +50 mV that preceded the test pulse by 60 ms. a, Nav1.2, V484A, and L849C. b, Nav1.2, F852A, and L855C. c, Nav1.2, L854C/PRE with a prepulse, and L854C/NP without a prepulse. d, Nav1.2, V857C, F858C, and L860C.