Table 3.
Serum PON1 activities and PON1 genotypes in lead workers.
| PON1 genotype | Arylesterase (μmol/min/mL) | Paraoxonase (μmol/min/L) | Diazoxonase (μmol/min/L) |
|---|---|---|---|
| Q192R | |||
| QQ (n = 61) | 124.5 ± 30.9 | 382.9 ± 130.5 | 11,113 ± 2,797 |
| QR (n = 256) | 102.6 ± 30.0 | 723.3 ± 294.2 | 7,893 ± 2,768 |
| RR (n = 210) | 76.5 ± 27.5 | 1035.5 ± 391.3 | 3,223 ± 1,594 |
| p-Value | < 0.001 | < 0.001 | < 0.001 |
| −108C/T | |||
| CC (n = 154) | 112.0 ± 33.8 | 696.7 ± 379.4 | 8,693 ± 3,560 |
| CT (n = 265) | 93.0 ± 30.4 | 826.3 ± 396.0 | 6,206 ± 3,334 |
| TT (n = 108) | 74.2 ± 26.0 | 935.4 ± 335.2 | 3,629 ± 2,113 |
| p-Value | < 0.001 | < 0.001 | < 0.001 |
| L55M | |||
| LL (n = 497) | 95.3 ± 33.5 | 831.2 ± 387.0 | 6,438 ± 3,698 |
| LM (n = 30) | 84.5 ± 28.1 | 507.1 ± 251.6 | 5,856 ± 2,666 |
| p-Value | < 0.001 | < 0.001 | < 0.001 |
Allele frequencies for polymorphisms are as follows: Q192R, Q = 0.359, R = 0.641; −108C/T, C = 0.544, T = 0.456; and L55M, L = 0.972, M = 0.028. No individuals were homozygous for the M allele in this cohort. Data are mean ± SD. Statistical significance between genotypes was analyzed by one-way ANOVA and Scheffe test.