Fig. 2.

Impaired glucose tolerance in high-fat-fed Adipoq^−/− mice. A: similar glucose tolerance in chow-fed wild-type and Adipoq^−/− mice; n = 4 male mice/ genotype. B: impaired glucose tolerance in high-fat-fed Adipoq^−/− mice. At 3 mo of age, mice were fed a high-fat diet for 15 wk, and glucose tolerance tests were performed after an overnight fast; n = 7 male mice/genotype. Areas under the curves (A and B, bottom) were calculated using the trapezoid rule, and the means were compared with a one-way ANOVA followed by a Newman-Keuls multiple comparison test. *P < 0.05 vs. high-fat Adipoq^+/+ mice.