Fig. 5.

Adiponectin is not required for the improved glucose tolerance of mice lacking DGAT1. A: DGAT1 deficiency protects against impairment in fasting glucose associated with high-fat feeding, even in the absence of adiponectin. B and C: DGAT1 deficiency protects against diet-induced glucose intolerance in mice regardless of the presence or absence of adiponectin. Mice (n = 5–12 male mice/genotype) were fed a high-fat diet for 8 wk. After an overnight fast, blood glucose was measured (A). Glucose tolerance tests were performed in B. C: area under the curves was calculated as described in Fig. 2. *P < 0.05 vs. mice with the same Dgat1 genotype; †P < 0.05 vs. mice with the same Adipoq genotype.