TABLE 2.
Cellularity in hematopoietic organs of Hoxb3/b4-deficient mice
| Mouse genotypea | Mean ± SDb
|
|||||
|---|---|---|---|---|---|---|
| Spleen wt (mg) | Spleen cellularity (106) | RBC count (1012/liter) | Hemoglobin level (g/liter) | WBC count (109/liter) | BM cellularity (two femurs [106]) | |
| Hoxb3/b4+/+ | 103 ± 14 | 187 ± 30 | 8.1 ± 0.8 | 151 ± 10 | 4.1 ± 1 | 45 ± 6 |
| Hoxb3/b4−/− | 70 ± 7 | 127 ± 24 | 7.4 ± 0.7 | 139 ± 10 | 3.8 ± 1 | 34 ± 5 |
a
Ten mice per genotype, each at 12 to 16 weeks of age.
b
The P values for the hematopoietic parameters were as follows: spleen weight, <0.001; spleen cellularity, 0.001; red blood cell (RBC) count, 0.05; hemoglobin level, 0.03; white blood cell (WBC) count, 0.5; and BM cellularity, 0.003.