Homology comparison of the BAd3 fiber knob with the corresponding region of PAd3 and HAd5 fibers using CLUSALW alignment software. Identical, similar, and related residues are depicted by asterisks (and highlighted), colons, and dots, respectively. The HAd5 fiber knob residues that are known to be important for CAR-binding or that peripherally involved in CAR-binding are underlined or shown in bold, respectively.