Figure 1.

Structure of the KIAA0187 gene and its human paralogs. (A) Schematic of KIAA0187 intron/exon organization. The size of each intron is given in base pairs below the schematic. Nucleotide positions defining each exon are shown above the schematic, taking the A of the initiation codon as position 1 because the transcription start site has not been defined. All splice sites conform to the GT-AG rule. Untranslated regions are indicated in grey, and exon numbers are shown when resolution allows. (B) Physical structure of human paralogs. Solid horizontal lines indicate the extent of paralogy relative to the KIAA0187 gene. Solid vertical bars are shown when the terminus of paralogy can be defined; arrows are shown when it cannot be defined because of the incomplete nature of the sequence. Paralogous sequences that are contiguous within a single clone but are physically separated within the KIAA0187 gene are indicated by a dashed line joining the domains of paralogy. The positions of satellite arrays are shown if they are present within 1 kb of the terminus of paralogy. The chromosome 22 paralogs (ap000525/526 and d87003/d87018) have been characterized previously (Dunham et al. 1999; Eichler et al. 1999; Guy et al. 2000). Physical scale in kilobases is shown relative to Guy et al. (2000).