Ctf3p, Mcm22p, Mcm16p, and Ctf19p coimmunoprecipitate
from yeast lysates. The indicated strains were grown to log phase,
lysed and anti-Myc immunoprecipitations were performed. Forty
micrograms of whole-cell lysate (L) and 25% of total immunoprecipitate
(IP) were loaded on the gel. Western blots were performed to detect
Myc- or HA-tagged proteins. The yeast strains used were: (A)
untagged (No Tag, YVM100), Mcm22p–HA (YVM210), Ctf3p–Myc (YVM218),
Mcm22p–HA Ctf3p–Myc (YVM255); (B) untagged (No Tag, YVM100),
Mcm22p–Myc (YVM 290), Mcm16p–HA (YVM344), Mcm16p–HA Mcm22p–Myc
(YVM346); (C) untagged (No Tag, YVM100), Ctf3p–Myc (YVM218),
Mcm16p–HA (YVM344), Ctf3p–Myc Mcm16p–HA (YVM336); and (D)
untagged (No Tag, YVM100), Ctf3p–Myc (YVM218), Ctf3p–Myc
ctf19Δ (YVM400), Mcm22p–Myc (YVM 290), Mcm22p–Myc
ctf19Δ (YVM398), Mcm16p–Myc (YVM325), Mcm16p–Myc
ctf19Δ (YVM402). Asterisks are IgG antibody light chain.