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Model for DV minus strand RNA synthesis. The viral genome circularizes in the absence of proteins mediated by 5′– 3′ UAR and 5′–3′ CS hybridization. The viral RdRp binds to a 5′ stem–loop (SLA), and by long-range RNA–RNA interactions the polymerase is transferred to the site of initiation at the 3′ end of the genome.
