Figure 4.

Schematic representation of the network of contact arrays of target proteins and clathrin within a coat. Key features illustrated are: 1, the contact between the clathrin terminal domain (yellow) and the clathrin-box sequences (black) in β-arrestins (green) and the β-chain of AP complexes (blue); 2, a possible additional contact (see text) between β-arrestins and terminal domain; 3, a contact, inferred from mutational studies between the carboxyl-terminal part of β-arrestins and the β-subunit of AP-2. APs are generalized adaptors for sorting signals (YppØ, LL) in various receptors; β-arrestins are specific adaptors for seven-transmembrane, G protein-coupled receptors (dark blue). The membrane is shown in gray; the framework of the clathrin coat is shown in red.