Table 1.
Concordantly up-regulated genes upon treatment with CDDO-Im
| Gene symbol | Gene name | Gene function | Cell line | Array1 | Pos.2 | |
| iMyc-1 | iMyc-2 | |||||
| Arc | activity regulated cytoskeletal-associated protein | CARD family | 2.4 | 47 | Apo | C1 |
| Bcl2 | B-cell leukemia/lymphoma 2 | Bcl2 family | 2.2 | 2.9 | Apo | C2 |
| Biklk | Bcl2-interacting killer-like (Bik) | Bcl2 family | 2.4 | 2.0 | Apo | B3 |
| Casp8 | caspase 8 | caspase family | 5.5 | 4.6 | Apo | H5 |
| Tox | G1 | |||||
| Casp9 | caspase 9 | caspase family | 10 | 6.5 | Apo | B6 |
| Casp14 | caspase 14 | caspase family | 15 | 23 | Apo | C5 |
| Creb1 | cAMP responsive element binding protein 1 | transcription factor | 2.1 | 2.8 | Cycle | E1 |
| NFκB | E1 | |||||
| Csf2 | colony stimulating factor 2 | cytokine | 3.4 | 5.9 | NFκB | G1 |
| Cyp2a4 | cytochrome P450, family 2, subfamily a, polypeptide 5 | oxidative/metabolic stress | 25 | 20 | Tox | A3 |
| Cyp2b9 | cytochrome P450, family 2, subfamily b, polypeptide 9 | oxidative/metabolic stress | 14 | 14 | Tox | C3 |
| Cyp2c29 | cytochrome P450, family 2, subfamily c, polypeptide 29 | oxidative/metabolic stress | 14 | 434 | Tox | D3 |
| Cyp4a10 | cytochrome P450, family 4, subfamily a, polypeptide 10 | oxidative/metabolic stress | 4.9 | 4.5 | Tox | F3 |
| Egr1 | early growth response 1 | oxidative/metabolic stress | 2.5 | 3.9 | NFκB | A2 |
| Fmo4 | flavin containing monooxygenase 4 | oxidative/metabolic stress | 286 | 145 | Tox | D5 |
| Gadd45a | growth arrest and DNA-damage-inducible 45 alpha | ATM/p53 pathway | 2.4 | 2 | Apo | E7 |
| Tox | F5 | |||||
| Gstm1 | glutathione S-transferase, mu 1 | oxidative/metabolic stress | 4.4 | 16 | Tox | C6 |
| Gstm3 | glutathione S-transferase, mu 3 | oxidative/metabolic stress | 2.4 | 3.3 | Tox | D6 |
| Hmox1 | heme oxygenase (decycling) 1 | oxidative/metabolic stress | 10 | 12 | Tox | E6 |
| Ifna1 | interferon alpha family, gene 1 | cytokine | 4.9 | 7.9 | NFκB | A3 |
| Ifng | interferon gamma | inflammation | 2.0 | 2.8 | NFκB | C3 |
| Il1b | interleukin 1 beta | inflammation | 4.0 | 11 | NFκB | A4 |
| Il1r2 | interleukin 1 receptor, type II | inflammation | 2.1 | 2.0 | NFκB | C4 |
| Lta | lymphotoxin A | TNF ligand family | 4.1 | 65 | Apo | G7 |
| NFκB | E5 | |||||
| Nol3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | apoptosis/necrosis | 64 | 8.4 | Apo | E8 |
| Scya3 | chemokine (C-C motif) ligand 3 (Mip-1 alpha) | inflammation | 5.5 | 25 | Tox | H10 |
| Scyb10 | chemokine (C-X-C motif) ligand 10 | inflammation | 2.7 | 4.3 | Tox | B11 |
| Tnfrsf11a | tumor necrosis factor receptor superfamily, member 11a (RANK) | TNF ligand family | 2.7 | 102 | Apo | D9 |
| NFκB | G11 | |||||
| Tnfrsf25 | tumor necrosis factor (ligand) superfamily, member 6 (CD178, CD95L, Fasl, gld) | apoptosis/necrosis | 9.6 | 37 | Apo | F9 |
| Tnfsf6 | tumor necrosis factor (ligand) superfamily, member 6 | TNF ligand family | 12 | 8.2 | Tox | H11 |
| Ugt1a1 | UDP-glucuronosyltransferase 1 family, member 1 | DNA damage/repair | 4.6 | 6.8 | Tox | C12 |
1GEArray Q series mouse cDNA gene arrays (SuperArray Bioscience Corporation, Gaithersburg, MD) included the MM-001 cell cycle array (Cycle), MM-002 apoptosis array (Apo), MM-012 stress and toxicity array (Tox) and MM-016 NFκB signaling array (NFκB).
2Array position, as indicated in Figure 3