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. Author manuscript; available in PMC: 2007 Jul 1.
Published in final edited form as: Trends Cardiovasc Med. 2006 Jul;16(5):163–168. doi: 10.1016/j.tcm.2006.03.006

Figure 1.

Figure 1

Circulating transcriptomes reveal makers of atherosclerosis. A) Illustration depicting the concept of genes by circulating cells in blood directly or indirectly reflecting atherosclerotic heart vessels. The red speckles represent the products of genes that may be important in heart attacks. By non-invasively querying circulating cells in patients with atherosclerosis, FOS gene was identified out of six candidates as being highly expressed in those with more extensive disease (color-coded panel: higher levels, red; lower levels, green). B) Schematic outline of purifying CD14+ monocytes with magnetic bead-conjugated antibodies from Disease and Normal blood samples followed by serial analysis of gene expression (SAGE) to identify atherosclerosis marker (Disease) genes. These are then confirmed by RT-PCR using known test samples before examining larger groups of subjects in a clinical study.