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. 2003 Jun;185(11):3278–3287. doi: 10.1128/JB.185.11.3278-3287.2003

FIG. 8.

FIG. 8.

Comparison of PM2 protein P14 with some archaeal and eukaryotic transcription regulators with zinc finger motifs. (A) The polypeptides are aligned (horizontal lines) so that the cysteine residues match (vertical lines). Aligned proteins PM2 P14, as well as HsTFIIS and ScTFIIS, have only one zinc finger domain (indicated by two cysteine pairs), whereas the others contain two. (B) The amino acid (aa) sequence from the shadowed area in panel A is shown. Identical amino acids between P14 and related sequences are shaded gray, and the cysteines of the zinc finger domain are boxed. Note that there is an alternative way to align the second cysteine pair in P14. Abbreviations: Tc, Thermococcus celer; Sa, Sulfolobus acidocaldarius; Sc, Saccharomyces cerevisiae; Hs, Homo sapiens; RpoM, archaeal RNA polymerase subunit M; RPA12 and RPB9, eukaryotic RNA polymerase I and II subunits, respectively, TFIIS, eukaryotic general transcription factor. Accession numbers: AAD43545 (PM2 P14), Q56254 (TcRpoM), CAA50073 (transcription-associated protein from Sa), AAA34992 (ScRPA12), AAG50159 (HsRPA12), P27999 (ScRPB9), P36954 (HsRPB9), P07273 (ScTFIIS), NP_006747 (HsTFIIS).