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Organization of the scFv targeting domain and Fc effector domain of an immunoconjugate molecule. VH and VL, heavy chain and light chain variable regions, respectively, derived from a scFv fusion-phage clone (7); a (G4S)3 polypeptide (curved line) links the VH to the VL region. H, hinge region of a human IgG1 Ig containing two disulfide bridges. CH2 and CH3, second and third constant regions of a human IgG1 Ig.
