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. 1974 Apr;16(4):541–552.

Surface immunoglobulins in chronic lymphatic leukaemia, macroglobulinaemia and myelomatosis

W Knapp, Henrica R E Schuit, R L H Bolhuis, W Hijmans
PMCID: PMC1554004  PMID: 4219765

Abstract

The direct method of immunofluorescence was applied for the detection of surface immunoglobulins (Ig) on lymphocytes, obtained from bone marrow and peripheral blood, especially from patients with paraproteinaemia. The results in chronic lymphatic leukaemia (CLL), in the macroglobulinaemia of Waldenström (MW), and in multiple myeloma (MM) show three different patterns as far as the relationship between cytoplasmic and membrane Ig is concerned. In CLL a monoclonal proliferation of cells with surface Ig was found, but the percentage of cells with cytoplasmic fluorescence was normal. In MW the further differentiation in Ig-secreting cells seems to be intact. In MM the percentage of lymphocytes in the peripheral blood with membrane-bound Ig was within normal limits or decreased.

These data suggest that MM can be considered as a neoplasia of already differentiated Ig-secreting cells, localized in the bone marrow. The combined information again indicates the central role of human bone marrow for antibody production.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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