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. 1974 May;17(1):199–207.

Studies of the Corynebacterium parvum-associated anaemia in mice

K O Cox, D Keast
PMCID: PMC1554057  PMID: 4466596

Abstract

The results suggest that the anaemia in mice associated with the injection of C. parvum is mediated by an immune mechanism. Survival studies of 51Cr-labelled red blood cells (RBC) in splenectomized and unsplenectomized mice show that mice immunized with C. parvum three times, clear RBC faster than unimmunized mice. However, hyperimmunized mice stabilized their haemoglobin concentrations above their minimum level and did not clear 51Cr-labelled RBC faster than unimmunized mice. All mice produced antibody against C. parvum but remained direct Coombs'-negative. Serum from immunized animals did not contain opsonins for 51Cr-labelled RBC. The reticulocytosis, normal osmotic fragility tests and normal survival times of 51Cr-labelled RBC from C. parvum-immunized mice all suggest that the main direct influence of the micro-organism is extrinsic of the RBC. Antigens from the micro-organism were adsorbed by erythrocytes in vitro. It is hypothesized that the anaemia is caused by destruction of RBC brought about by anitbody reacting with bacteria that have been adsorbed by RBC.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brodsky I., Kahn S. B. Effect of a leukemia virus on erythropoiesis. J Natl Cancer Inst. 1969 Jan;42(1):39–49. [PubMed] [Google Scholar]
  2. Brodsky I., Reilly C. A., Jr, Schloss G. T. Correspondence. Cancer Res. 1971 Oct;31(10):1513–1514. [PubMed] [Google Scholar]
  3. Carstairs K. Drug-induced immune haemolysis. Proc R Soc Med. 1968 Dec 12;61(12):1309–1311. doi: 10.1177/003591576806101236. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cox K. O., Keast D. Abelson virus activity in mice and rats neutralized with anti-Rauscher virus serum. J Natl Cancer Inst. 1973 Aug;51(2):671–673. [PubMed] [Google Scholar]
  5. Cox K. O., Keast D. Erythrocyte autoantibodies induced in mice immunized with rat erythrocytes. Immunology. 1973 Sep;25(3):531–539. [PMC free article] [PubMed] [Google Scholar]
  6. Croft W. A., Bryan G. T. Production of urinary bladder carcinomas in male hamsters by N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide, N-(4-(5-nitro-2-furyl)-2-thiazolyl)-acetamide, or formic acid 2-(4-(5-nitro-2-furyl)-2-thiazolyl)hydrazide. J Natl Cancer Inst. 1973 Sep;51(3):941–949. doi: 10.1093/jnci/51.3.941. [DOI] [PubMed] [Google Scholar]
  7. GORZYNSKI E. A., LUDERITZ O., NETER E., WESTPHAL O. The bacterial hemagglutination test for the demonstration of antibodies to Enterobacteriaceae. Ann N Y Acad Sci. 1956 Aug 10;66(1):141–156. doi: 10.1111/j.1749-6632.1956.tb40113.x. [DOI] [PubMed] [Google Scholar]
  8. HALPERN B. N., PREVOT A. R., BIOZZI G., STIFFEL C., MOUTON D., MORARD J. C., BOUTHILLIER Y., DECREUSEFOND C. STIMULATION DE L'ACTIVIT'E PHAGOCYTAIRE DU SYST'EME R'ETICULOENDOTH'ELIAL PROVOQU'EE PAR CORYNEBACTERIUM PARVUM. J Reticuloendothel Soc. 1964 Jan;1:77–96. [PubMed] [Google Scholar]
  9. Halpern B., Fray A. Déclenchement de l'anémie hémolytique autoimmune chez de jeunes souriceaux NZB par l'administration de Corynebacterium parvum. Ann Inst Pasteur (Paris) 1969 Dec;117(6):778–789. [PubMed] [Google Scholar]
  10. McCracken A., McBride W. H., Weir D. M. Adjuvant-induced antired blood cell activity in CBA mice. Clin Exp Immunol. 1971 Jun;8(6):949–955. [PMC free article] [PubMed] [Google Scholar]
  11. Woodruff M. F., Boak J. L. Inhibitory effect of injection of Corynebacterium parvum on the growth of tumour transplants in isogenic hosts. Br J Cancer. 1966 Jun;20(2):345–355. doi: 10.1038/bjc.1966.42. [DOI] [PMC free article] [PubMed] [Google Scholar]

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