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. 1991 Dec;86(3):483–488. doi: 10.1111/j.1365-2249.1991.tb02957.x

Autoantibodies against Forssman glycolipids in Graves' disease and Hashimoto's thyroiditis.

T Ariga 1, T Yoshida 1, T Mimori 1, R K Yu 1
PMCID: PMC1554196  PMID: 1747956

Abstract

Sera from patients with Graves' disease and Hashimoto's thyroiditis have been shown to react with the Forssman glycolipid antigen (Gb5) using the techniques of high performance thin-layer chromatography (HPTLC) immunostaining and ELISA. Human monoclonal antibodies (MoAbs) have been prepared by fusion of human myeloma with peripheral lymphocytes from patients with Graves' disease. A MoAb, TRMo-4, reacted strongly and specifically with Gb5. These results suggest that anti-Forssman antibody may be involved in the pathogenesis of these autoimmune diseases. The detection of anti-Forssman glycolipid antibody may provide a useful means for clinical diagnosis and therapy.

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Selected References

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