Figure 2.

Nucleotide sequence of a rat epiregulin cDNA transcript and the deduced amino acid sequence of rat epiregulin precursor protein. (A) Nucleotide sequence of rat epiregulin cDNA. The underlined amino acid sequence indicates residues that were identified by N-terminal amino acid sequencing. (B) Alignment of rat, mouse, and human epiregulin polypeptides. The mature rat epiregulin peptide is underlined (amino acids 56–101). A period indicates that an amino acid is identical to the one in the rat peptide at a given position; a hyphen indicates that no corresponding amino acid occupies the indicated position.