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. Author manuscript; available in PMC: 2007 Aug 1.
Published in final edited form as: J Neurophysiol. 2006 May 17;96(2):677–685. doi: 10.1152/jn.00336.2006

FIG. 4.

FIG. 4

Comparison of fEPSPs and theta-burst responses in slices prepared from middle-aged rats that had received vehicle or ampakine injections. Plots A-C show results from recordings within str. radiatum and plots D-G show results from recordings within str. oriens. A: theta bursts were delivered to the Schaffer-commissural projections to the apical dendrites (str. radiatum) of field CA1. Graph summarizes the mean sizes (±SEs) of fEPSPs collected from hippocampal slices prepared from CX929-treated (closed circles) or vehicle-treated (open circles) middle-aged rats. There were no reliable differences in percentage potentiation between the two groups (P>0.3 for minutes 50-60). B and C: input/output (I/O) curves were generated for slices represented in A by stimulating the Schaffer-commissural afferents to CA1 apical dendrites at a constant current (30 μA) with varying pulse durations. Representative traces (B) from slices of vehicle- vs. CX929-treatment groups were not detectably different. Group data (C) showed no effect of CX929 on fEPSP amplitudes (P>0.4). D and E: I/O curves were generated for basal dendritic, Schaffer-commissural fEPSP responses of slices represented in Fig. 3. D: representative traces generated from increasing stimulus duration steps were not detectably different for slices from vehicle- and CX929-treated animals. E: group I/O data from str. oriens showed no effect of CX929 on fEPSP amplitude (P>0.5, n = 12/group). F and G: size and waveforms of theta-burst responses within the CA1 basal dendrites (str. oriens) were compared in vehicle- and ampakine-treated middle-aged rats (same as represented in D and E). F: records from 5 slices were averaged to produce representative responses to the first and fourth theta bursts. G: graph showing facilitation of str. oriens theta-burst responses during a 10-burst train for vehicle-treated (open bars) and CX929-treated (closed bars) rats. Response size was calculated as the percentage increase of the area of measured burst response over the area of the first burst response. Plot shows group means (±SE) for bursts 2-10. Within-train burst-response profile was not statistically different for slices from ampakine- and vehicle-treated rats (n = 12/group).