Table 2.
The risk of tubal pathology (TP) in relation to the genotype of the single genes studied.
| 1.1 | 1.2 and 2.2 | ||||
| n | Risk of TP | n | Risk of TP | ||
| TLR9 -1237 T>C | All subfertile women | 155 (68%) | 20% | 72 (32%) | 17% |
| CT+ subfertile women | 26 (67%) | 62% | 13 (33%) | 77% | |
| Control group | 66 (68%) | - | 31 (32%) | - | |
| TLR9 +2848 G>A | All subfertile women | 45 (20%) | 18% | 182 (80%) | 19% |
| CT+ subfertile women | 6 (15%) | 50% | 33 (85%) | 70% | |
| Control group | 15 (15%) | - | 82 (85%) | - | |
| TLR4 +896 A>Ga | All subfertile women | 200 (88%) | 19% | 27 (12%) | 22% |
| CT+ subfertile women | 33 (85%) | 64% | 6 (15%) | 83% | |
| Control group | 87 (90%) | - | 10 (10%) | - | |
| CD14 -260 C>Tb | All subfertile women | 60 (26%) | 17% | 167 (74%) | 20% |
| CT+ subfertile women | 12 (31%) | 67% | 27 (69%) | 67% | |
| Control group | 26 (27%) | - | 71 (73%) | - | |
| CARD15/NOD2 | All subfertile women | 211 (93%) | 18% | 16 (7%) | 25% |
| Leu1007fsinsC | CT+ subfertile women | 37 (95%) | 65% | 2 (5%) | 100% |
| (SNP13) | Control group | 95 (98%) | - | 2 (2%) | - |
All subfertile women: n = 227, of whom 19% has tubal pathology (TP).
CT + (C. trachomatis IgG-positive) subfertile women: n = 39, of whom 67% has TP.
Control group: n = 97 ethnically-matched healthy employees of the VU University Medical Center.
1.1 = normal genotype (homozygous for the common allele); 1.2 = heterozygous SNP carrier (one common allele and one rare allele); 2.2 = homozygous SNP carrier (homozygous for the rare allele).
a Adapted from Morré et al., 2003 [1].
b Adapted from Ouburg et al., 2005 [2].