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. 2006 Sep 1;116(9):2493–2499. doi: 10.1172/JCI27726

Figure 4. Role of JNK in TRAIL-mediated sensitization of Fas-induced apoptosis.

Figure 4

(A) Wild-type (TRAIL+/+) or TRAIL-deficient mice (TRAIL–/–) were injected with PBS or anti-Fas antibody and euthanized at indicated time points. Liver protein samples were analyzed for phospho-JNK (p-JNK), active caspase 3, and JNK as loading control. Two mice per group are shown. (B) Serum transaminase levels (AST) were analyzed in wild-type and TRAIL-deficient mice at indicated time points after anti-Fas injection. Mean values ± SD of 3 mice per group are shown. (C) Wild-type mice were injected i.p. with control or JNK inhibitor SP600125 (inh) prior to injection of anti-Fas antibody. Serum transaminase levels (AST) were analyzed after 4 hours. Bars represent mean values ± SD of 7 mice per group. Statistical differences were analyzed by Student’s t test. *P < 0.01.