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Male and female Insig-1+/–Insig-2–/– mice were mated, and the resultant embryos were collected at 18.5 dpc, photographed, and genotyped. Lateral (A) and palatal views (B) of control (Insig-1+/+Insig-2–/–littermate) and Insig-DKO embryos with cleft palate or cleft face. The lower jaw was resected to reveal the oral cavity. Black arrows indicate cleft palate; white arrows indicate cleft face. pa, palate; tg, tongue. Scale bars: 2.5 mm.
