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sIgM−/− mice spontaneously developed elevated levels of IgG3 specific to dsDNA. Sera from 12-month-old wild-type (○) and sIgM−/− (●) females were assayed by ELISA for the levels of IgG specific to dsDNA. *, P value of <0.0006 between wt and sIgM−/− mice. Values below “//” are considered below the detection of the assay.
