Figure 2.

Ability of recombinant human and mouse IL-18BP isoforms to inhibit IL-18 biological activities. Supernatants from transiently transfected COS cells were assayed on (A) human PBMC, (B) human NKO cell line, and (C) mouse spleen cells. Supernatants were removed and dialyzed against PBS and added to each cell culture undiluted. Data are mean ±SEM IFN-γ levels of three experiments. Mock indicates supernatants from COS cells transiently transfected with the empty vector.