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4-AP decreases estradiol production by PGC-2 cultures. A) Accumulation of progesterone in media of PGC-2 (n = 4 culture wells) cultured with pregnenolone (1 μg/ml), androstenedione (100 μM), or 5α-dihydrotestosterone (5α-DHT, 100 μM). B) Accumulation of estradiol in media of PGC-2 (n = 4 culture wells) cultured with androstenedione (100 μM). In all panels, asterisk indicates P < 0.05 compared with PGC-2 cultured under similar conditions in the absence of 4-AP.
