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Anxiety-related behavior in the elevated zero maze. (A) Total distance traveled is slightly reduced for GAD65−/− mice (n = 10 for each genotype). (B) GAD65−/− mice spend almost 50% less time in the open area of the elevated zero maze. (C) GAD65-deficient mice venture fewer times onto the open arm. Values represent the mean ± SEM. Filled columns, GAD65+/+; open columns, GAD65−/−. ∗, P < 0.05 between genotypes (Student’s t test); ∗∗, P < 0.01 between genotypes (Student’s t test).
