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Dose-response curve for diazepam. Distance traveled in centimeters for the first 10 min after drug administration is indicated as a function of diazepam dose. Data are shown as mean ± SEM. Wild-type mice (■) show a typical locomotor activating effect at low doses, which is absent in the GAD65−/− mice (□). V, vehicle. ∗, P < 0.05 between genotypes (Tukey test); #, P < 0.05 compared with vehicle (Tukey test).
