Figure 1.

Schematic diagram of β-amyloid. The amino acid sequence of human Aβ (box), the major known sites of Aβ cleavage and of secretase actions (α, β, and γ), and the antibodies used (22C11 directed at the N-terminal region of βAPP; 6E10 directed at human Aβ1–10; 3431N directed at the N-terminal region of rodent Aβ; 4G8 directed at Aβ17–24; and 369 directed at the C-terminal region of βAPP) are shown.