Figure 6.

External and internal images of bone metastasis of AC3488 GFP. External fluorescent whole-body images compared with direct images of skeletal metastases. (A) External images of tumors in the skeletal system including the skull (arrow heads), scapula (thick arrows), spine (fine arrows), and liver metastasis (largest arrows) in a dorsal view of live, intact nude mouse. (B–I) Series of external fluorescence images of metastatic lesions in the skull, ribs, spine, and tibia, (B, D, F, and H) compared with corresponding images of the exposed skeletal metastases (C, E, G, and I) (Bars = 1280 μm).