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. 1999 Feb 16;96(4):1716–1721. doi: 10.1073/pnas.96.4.1716

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Copyright © 1999, The National Academy of Sciences

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ZnT3 immunocytochemistry in the ZnT3^+/+ (A and B), ZnT3^+/− (C and D), and ZnT3^−/− (E and F) hippocampus. Compared with the ZnT3^+/+ hippocampus (A), ZnT3 immunoreactivity was reduced in many areas of the ZnT3^+/− hippocampus (C) and was undetectable in the ZnT3^−/− hippocampus (E). (B, D, and F) Electron micrographs of MFBs in s lucidum (boxed area in A, C, and E). ZnT3 immunoreactivity was conspicuous on synaptic vesicle membranes of ZnT3^+/+ MFBs (B), reduced on vesicle membranes of ZnT3^+/− MFBs (D), and undetectable on vesicle membranes of ZnT3^−/− MFBs (F). The number of immunoreactive vesicles in the ZnT3^+/− and ZnT3^+/+ MFBs was approximately the same. Arrowheads point to synaptic contacts made with dendritic spines (S). H, hippocampus; DG, dentate gyrus; h, hilus; luc, s lucidum; or, s oriens; rad, s radiatum; ml, molecular layer.