FIG. 4.
Systemic and lung IFN-γ levels are increased after BCG/Cryptococcus coinfection. Mice were infected intranasally with 2 × 105 CFU of BCG or given PBS. After 6 weeks, Cryptococcus (Crypto) or PBS was administered intranasally and animals were sacrificed 13 days later. Serum (a) and BAL fluid (b) IFN-γ levels were determined by ELISA. The significant differences between groups are indicated in the figure. Each dot represents one animal, and the results are from one of two representative experiments.