TABLE 1.
Increased T-cell activation in BCG-immune mice infected with C. neoformansa
| Inoculum (a) | Granulocytesb | CD4+ CD45RBlo cellsc | CD8+ CD45RBlo cellsc | B cellsc | NK cellsc |
|---|---|---|---|---|---|
| Cryptococcus only | 54 +/− 5.9 | 24 +/− 9.0 | 4.4 +/− 1.8 | 14 +/− 1.1 | 2.8 +/− 0.9 |
| BCG only | 5.7 +/− 0.8d | 21 +/− 4.4 | 15 +/− 4.6d | 11 +/− 2.0d | 2.5 +/− 1.1 |
| BCG/Cryptococcus | 16 +/− 3.0d | 43 +/− 6.9d,e | 15 +/− 2.9d | 6.0 +/− 2.1d,e | 3.2 +/− 0.2 |
a
Values are mean percentages and standard deviations (five mice per group).
b
Granulocytes were identified by their forward- and side-scatter properties by using flow cytometry.
c
Percentages are for those within the lymphocyte population.
d
Significantly different (P < 0.05) from values for PBS/Cryptococcus-infected group.
e
Significantly different (P < 0.05) from values for BCG/PBS-infected group.