TABLE 2.
Prior exposure to BCG increases IFN-γ and TNF levels in C. neoformans-infected micea
| Inocula | CD4+ IFN-γ | CD8+ IFN-γ | CD4+ IL-5 | CD8+ IL-5 | CD4+ TNF | CD8+ TNF |
|---|---|---|---|---|---|---|
| PBS/Cryptococcus | 2.7 +/− 0.8 | 7.4 +/− 1.6 | 1.8 +/− 1.1 | 2.5 +/− 1.5 | 7.7 +/− 2.4 | 8.6 +/− 2.4 |
| BCG/Cryptococcus | 15 +/− 4.6b | 15 +/− 3.9b | 0.7 +/− 0.9 | 1.9 +/− 2.7 | 17 +/− 4.6b | 17 +/− 5.0b |
| BCG/PBS | 3.8 +/− 1.3c | 2.0 +/− 0.7b,c | 0.2 +/− 0.2b | 0.1 +/− 0.2b | NDd | NDd |
a
The values represent the mean percentages and standard deviations of CD4 or CD8 T cells expressing the cytokine indicated (five mice per group).
b
Significantly different (P < 0.05) from values for PBS/Cryptococcus-infected group.
c
Significantly different (P < 0.05) from values for BCG/PBS-infected group.
d
ND, not done due to inadequate number of cells.